Introducing of novel class of pyrano[2,3-c]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations
Ameliorative effect of ethoxylated chalcone-based MAO-B inhibitor on behavioural predictors of haloperidol-induced Parkinsonism in mice: evidence of its antioxidative role against Parkinson?s diseases
"Exploring the therapeutic potentials of highly selective oxygenated chalcone based MAO-B inhibitors in a haloperidol-induced murine model of Parkinson?s disease"
Vinayaka Missions University ,Salem, South INDIA - Vinayaka Missions University ,Salem, South INDIA
2013 - 2008
Certifications
Pharmacy council of the state of Kerala
23139
2000 - 2024
Projects
Assembling of phenyl substituted halogens in the C3-position of substituted isatins by monowave-assisted synthesis: Development of a new class of Monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease.
2024 - 2025
The discovery of selective, reversible, and competitive monoamine oxidase-B(MAO-B) inhibitors is
considered the prominent therapy for Parkinson’s disease (PD). The introduction of two hydrophobic units
which are separated by the electron-rich spacer is the new drug design strategy for the development of
selective MAO-B inhibitors. The current study aims to synthesize a series of Isatin-derived Schiff’s bases
by incorporating phenyl substituted halogens units. All the synthesized compounds will be subject to
