Assessment of Liver Enzymes Level Among Obese Sudanese Individuals in Khartoum State - Sudan

Overweight and obesity prevalence continues to increase and worldwide growing
epidemic health problems. Obesity imposes a significant effect on liver functions that may be
associated with a substantial risk factor for the development of several non-communicable
diseases, considerable disability, and premature death. To estimate and compare serum activity
of ALT, ALP, and GGT among healthy and obese Sudanese individuals. A total number of 80
participants were enrolled in this cross-sectional study, and they were categorized into 40
obese and 40 normal-weight individuals. Serum liver enzyme activity was measured for each
participant. A significant increase was found in ALT, ALP, and GGT levels among the obese group.
There is a statistical difference of GGT level mean between gender within the obese group. A
positive correlation was observed between the BMI and serum level of ALT (r=0.343, p =0.002),
ALP (r=0.503, p <0.001) and GGT (r=0.237, p= 0.034) and positive correlation between obesity
duration and GGT level (r=0.461, p =0.003). Study results revealed that obesity was associated
with a substantial elevation in liver enzymes that are considered risk factors for liver diseases in
Sudanese individuals.