fatma ahmed mohemd

A new series of 5-substituted-3-ethylindole-2-carboxamides 5a–k and 6a–c was designed and synthesised
in an attempt to develop a dual targeted antiproliferative agent. Various spectroscopic methods of analysis
were used to confirm the structures of the new compounds. The antiproliferative effect of compounds
5a–k and 6a–c against four cancer cell lines was investigated. Compounds 5a–k and 6a–c had significant
antiproliferative activity against the four cancer cell lines tested, with mean GI50 values ranging from 37 nM