Studies include: the mechanisms of polypeptide chain folding; the three-dimensional configuration of proteins; interactions of proteins with other proteins, nucleic acids and phospholipids; relationship between the plasma membrane and the cytoskeleton and extracellular matrix; and structure-function relations and domain structure of enzymes. Application of the current technology and techniques such as x-ray crystallography, multi-dimensional NMR spectrometry, scanning and transmission microscopy and atomic-force microscopy, tandem mass spectrometry, Fourier transform infrared spectrometry, recombinant DNA technology and computer simulation.