This course deals with the application of structure and theory to the study of organic reaction: isotope effects and molecular orbital theory applied to pericyclic and organic photochemical reactions; and special reactive intermediates including carbenes, carbanions, and free radicals. In addition, functional group interconversion by nucleophilic substitution (heterocyclic compounds). Recognition of functional groups are also covered. The course also distributed to electrophilic addition to carbon-carbon multiple bonds.