The Sirt1/Nrf2 pathway is a key factor for drug therapyin chemotherapy‑induced cardiotoxicity: a Mini‑Review

The likelihood of survival for cancer patients has greatly improved due to chemotherapy medicines. However, these anti-tumor agents might also have unfavorable effects on the cardiovascular system, which could result in sudden or gradualcardiac failure. The production of free radicals that result in oxidative stress appears to be the key mechanism by whichchemotherapy-induced cardiotoxicity (CIC) happens. Reports suggest that the Sirtuin-1 (Sirt1)/nuclear factor E2-associated factor 2 (Nrf2) signaling pathway has been considered an alternative path for counteracting cardiotoxicity by suppressing oxidative stress, inflammation, and apoptosis. This review concludes recent knowledge about CIC with a special focus on the anti-oxidative regulation properties of the Sirt1/Nrf2 pathway .