Design, Synthesis, and Antifungal Activity of Some New Thiazolo[4,5-d]pyrimidine-5-thione Derivatives

A new series of thiazolo[4,5-d]pyrimidine-5-thione derivatives having indole and phenyl moieties were synthesized. Their structures were established by spectral and elemental analyses. All newly synthesized thiazolo[4,5-d]pyrimidine-5-thione derivatives were subjected to antifungal testing against Rhizopus stolonifer and Aspergillus terreus. One of the tested compounds was found to be more active against Aspergillus terreus than Rhizopus stolonifer, and the other compounds were inactive against the same fungal strains.