Tridentate N-donor Schiff base metal Complexes: Synthesis, Characterization, computational Studies, and assessment of biomedical applications in cancer Therapy, Helicobacter pylori Eradication, and COVID-19 treatmen
Abstract
A unique Schiff base ligand (BCA), 4-(2-((1E,2E)-1-(2-(p-tolyl)hydrazono)propan-2-ylidene)hydrazinyl)quina
zoline, was synthesized and complexed with Mn [II], Co [II], Cu [II, and Cd [II] ions, with 1,10-Phenanthroline
(PHN) as an auxiliary ligand. The unique Schiff base ligand BCA and its metal complexes were characterized
using multiple analytical techniques, including elemental analysis, UV–visible spectroscopy, FT-IR, mass spec
trometry, and conductometric measurements. These methods provided detailed insights into the compounds’
structural and electronic properties.
Keywords
Molecular docking- Antimicrobial activity -Spectral studies - Anti-COVID-19 -Schiff base