Immobilization of novel inorganic nano-complexes onto MWCNT nanomaterials as a novel adsorbent and anti-inflammatory therapy in an induced model of rheumatoid arthritis

Novel supported inorganic metal nano-complexes of Ag(I) and Co(II) derived from
4-amino-N-(4-methylpyrimidin-2-yl) benzene sulfonamide (SulMer) were synthesized using
olive leaf extract as a reducing agent with grinding and microwave methods. The prepared
samples were denoted as Comp1–6. The surface morphologies of the synthesized nanomaterials
were analyzed using C, H, N, S analysis, Fourier-transform infrared spectroscopy, UV– visible
spectroscopy, proton and carbon nuclear magnetic resonance, scanning electron microscopy,
transmission electron microscopy, thermogravimetric analysis, and x-ray powder diffraction
(XRD) analysis. The data revealed that all the synthesized complexes exhibited a 1:1 metalto-ligand ratio with a coordination number of 4 or 6. The mean particle size of the nanomaterial
samples was 25–35 nm. The XRD patterns indicated a crystalline nature for the complexes. The
supported inorganic metal nano-complexes displayed good activity in the adsorptive removal of
Direct Red 81 (DR-81) from aqueous solutions. In addition , the effect of the supported metal
nano-complexes on the immune system was studied as well as how these anti-inflammatory
compounds could be used to treat many autoimmune diseases, most notably rheumatoid
arthritis. An experimental model for arthritis can be induced using complete Freund’s adjuvant.
It was shown that the supported complex offers several advantages such stability eco-friendliness, simple experimental conditions, short reaction times, and easy work- up