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Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds

Author name : Arafa Kassem A Musa
Publication Date : 2022-01-20
Journal Name : Journal of Inflammation Research

Abstract

Background and Purpose: Because of gastrointestinal irritation and kidney toxicity associated with non-steroidal anti-inflammatory drugs and the cardiovascular problems of Coxibs use, developing novel anti-inflammatory agents with reduced toxicity and improved selectivity remains a major challenge. Depending on our previous work, a novel series of pyridopyrimidinones IIIa-i has been synthesized via reaction of 6-amino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (I) and phenyldiazenyl aromatic aldehydes (IIa-i). All the new constructed compounds were fully characterized by elemental and spectral analysis.

Keywords

cyclooxigenase inhibitors, antiinflammatory activity, ulcerogenic effect, tricyclic pyridopyrimidines

Publication Link

https://doi.org/10.2147/JIR.S343263

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