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Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds

Author name : Arafa Kassem A Musa
Publication Date : 2022-11-07
Journal Name : Journal of Inflammation Research

Abstract

Background and Purpose: Because of gastrointestinal irritation and kidney toxicity associated with non-steroidal anti-inflammatory drugs and the cardiovascular problems of Coxibs use, developing novel anti-inflammatory agents with reduced toxicity and improved selectivity remains a major challenge. Depending on our previous work, a novel series of pyridopyrimidinones IIIa-i has been synthesized via reaction of 6-amino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (I) and phenyldiazenyl aromatic aldehydes (IIa-i). All the new constructed compounds were fully characterized by elemental and spectral analysis.
Methods: The target compounds IIIa–i were investigated for their potential towards COX inhibition, anti-inflammatory properties using carrageenan induced edema model in rat paw, and the ulcer indices of the most active members.
Results: The ethyl pyridopyrmidinone-benzoates IIIf, IIIg and IIIh showed superior.......

Keywords

cyclooxigenase inhibitors, antiinflammatory activity, ulcerogenic effect, tricyclic pyridopyrimidines

Publication Link

https://doi.org/10.3390/plants11141871

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