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Folate Metabolism: Impact of Involved Genetic Variants on Homocycteine and Folate Levels in Type 2 Diabetic Patients with Coronary Artery Disease.

Author name : RASHA LOTFY ALY ETEWA
Publication Date : 2020-12-01
Journal Name : - Meta gene -Elsevier BV

Abstract

Type2 diabetes mellitus (T2DM) has severe impacts on quality of life throughout the world. Coronary artery disease (CAD) is one of the most serious microvascular complications of T2DM.
Objective
To explore the relationship between plasma homocysteine (Hcy) and folate levels, and their related methylenetetrahydrofolate reductase (MTHFR) C677T and reduced folate carrier-1 (RFC-1) A80G genes polymorphism in T2DM accompanied by CAD.
Methods
This case-control study enrolled 120 T2DM patients, 60 of them had CAD, and 60 healthy control subjects. Plasma Hcy and folate were measured by ELISA and genotyping was performed by PCR-RFLP. Lipid profile was analyzed by spectrophotometer.
Results
Plasma Hcy was increased and folate was decreased in both diabetic groups in relation to control group. T2DM with CAD showed significant difference with T2DM group. Hcy

Keywords

Folate, homocysteine, Diabetes Mellitus,

Publication Link

https://doi.org/10.1016/j.mgene.2020.100817.

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