Design, Synthesis, and In Vitro Cytotoxic Activity of Certain 2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl] acetamide Derivatives.

With a view to finding new anticancer agents, different aryloxy groups wereattached to C² of the pyrimidine ring in2-[3-phenyl-4-(pyrimidin-4-yl)-1H-pyrazol-1-yl]acetamide in five steps using methyl3-methoxy-5-methylbenzoate as the key intermediate product. The anticanceractivity of the synthesized compounds was tested on 60 cancer cell lines at 10µM. One compound showed an appreciable cancer cell growth inhibition (about 20%)against eight cancer cell lines (HOP-92, NCI-H226, 79SNB-75, A498, SN12C, UO-31,T-47D, and MDA-MB-468).