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An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

Author name : Wael Abdelgayed Ahmed Arafa
Publication Date : 2018-05-27
Journal Name : Arkivoc

Abstract

An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-arylidene-2-phenyloxazol-5 (4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles.

Keywords

bisoxazolones, bisimidazoles

Publication Link

https://doi.org/10.24820/ark.5550190.p010.544

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