Skip to main content
 

 

 

Design, Synthesis, and Antimicrobial Activities of 1,2,3-Triazole Glycoside Clickamers

Author name : satti Elhassan Abdelaziz Amira
Publication Date : 2020-02-12
Journal Name : Molecules

Abstract

Bacterial resistance remains a significant threat and a leading cause of death worldwide, despite massive attempts to control infections. In an effort to develop biologically active antibacterial and antifungal agents, six novel aryl-substituted-1,2,3-triazoles linked to carbohydrate units were synthesized through the Cu(I)-catalyzed azide-alkyne cycloaddition CuAAC of substituted-arylazides with a selection of alkyne-functionalized sugars. The chemical structures of the new derivatives were
verified using different spectroscopic techniques. The novel clicked 1,2,3-triazoles were evaluated for in vitro antibacterial activity against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa, and the obtained results were compared with the activity of the reference antibiotic “Ampicillin”. Likewise, in vitro antifungal activity of the new 1,2,3-triazoles was investigated against Candida albicans and Aspergillus niger using “Nystatin” as a reference drug.
The results of the biological evaluation pointed out that Staphylococcus aureus was more susceptible to all of the tested compounds than other examined microbes. In addition, some tested compounds exhibited promising antifungal activity.

Keywords

1,2,3-triazole; glycoside; click chemistry; antibacterial; antifungal

Publication Link

https://www.mdpi.com/1420-3049/25/4/790

Block_researches_list_suggestions

Suggestions to read

“Synthesis and Characterization study of SnO2/α-Fe2O3, In2O3/α-Fe2O3 and ZnO/α-Fe2O3 thin films and its application as transparent conducting electrode in silicon heterojunction solar cell”
Asma Arfaoui
Oral cancer stem cells: A comprehensive review of key drivers of treatment resistance and tumor recurrence
DR KALADHAR REDDY AILENI
Modeling the Social Factors Affecting Students Satisfaction with Online Learning: A Structural Equation Modeling Approach
ABDULHAMEED RAKAN ALENEZI
Higher Knee Muscles Co-Contractions are Observed in Individuals Exhibiting Loading Asymmetry Early after ACL Reconstruction. The Combined Sections Meeting
ABDULMAJEED BARAKAT MUBARAK ALFAYYADH
Contact