Biosynthesis of Zn-nano complex using Olive seeds forAntimicrobial Regulation of Nanostructured Materials

Dandruff affects a large number of people throughout the world.
Microsporum
spp. and
Nannizzia
spp. are fungal species connectedwith dandruff because they increase keratinocyte cytokine production (epidermal cells synthesizing keratin). Because dandruff is sucha bothersome problem for individuals, many efforts are being made to resolve this issue. This study focused on the synthesis of the freeligand (E)-N-(4,6-dimethy1pyrimidin-2-yl)-4-(((2-hydroxynaphtha1en-1-yl) methylene) amino) benzenesulfonamide by reacting 1-hydroxy-2-naphthaldehyde and amino-N-(4,6-dimethy1pyrimidin-2-yl) 4benzenesulfonamide. Its complex with Zn (II) was alsobiosynthesized as a nano complex in the presence of olive seed extracts. The nano complex was characterized by different methodssuch as elemental analyses, FT-IR, and SEM. The olive seeds were collected, shade-dried, powdered, and aquas extracted. The resultsobserved that the same MIC value of 12.5 mg/ml was recorded for
Microsporum canis
and
Microsporum gypseum
. However, a lower MICof 6.25 mg/ml was recorded for
Nannizzia fulva
. On the other hand, the MIC values recorded for Zn-nano complexes were lower thanthose recorded for the olive seed extract. These values were recorded as 6.25 mg/ml for
Microsporum canis
compared with 3.12 mg/mlfor both
Microsporum gypseum
and
Nannizzia fulva
. Well, a diffusion experiment was used to test the antifungal effects ofbiosynthesized nano complex. It was found that combining these nano complexes with shampoo boosts the anti-fungal impact againstdandruff-causing fungi (
Microsporum
spp. and
Nannizzia
spp.). This study demonstrates a simple, quick, and cost-effective method tobio-synthesis an effective nano-based complex with enhanced anti-fungal capabilities against dandruff-causing fungi.