Apoptotic Activity and Cytotoxic Effect of Convolvulus spicatus on Human Breast Cancer Cell Line (MCF-7)

Background and Objective: Despite advancements in modern therapeutic strategies, breast cancer still the most common cause of the high death rate among women worldwide. Wild plants and their extracts have been used in traditional medicine because of their efficient anti-cancer properties. This study aims to investigate in vitro the anti-cancer, anti-proliferative and potential therapeutic effects of Convolvulus spicatus (C. spicatus) methanolic extract against human breast cancer cell line Michigan Cancer Foundation-7 (MCF-7), besides putting shed on the mechanism of action of this extract. Materials and Methods: MTT (dimethylthiazol-diphenyltetrazolium bromide) cytotoxicity assay was done to evaluate C. spicatus methanolic extract's cytotoxic effects and its therapeutic potentiality against MCF-7 cells. Flow cytometry was used to clarify the potential impact of the different concentrations of the extract