تجاوز إلى المحتوى الرئيسي

Effects of Chronic Administration of Antipsychotic Drug (Olanzapine) on the Anterior Pituitary Gland of Adult Male Albino Rats and the Potential Protective Role of Hypericum Perforatum

Author name : Eman Shehata Ahmed Elroghy
Publication Date : 2024-03-01
Journal Name : EJH

Abstract

Introduction: Olanzapine (OLZ) is an atypical antipsychotic drug, has been used as approved therapy for schizophrenia and
bipolar disorder. Hypericum perforatum (HP) is a herbaceous plant, has been described as a neuroprotective agent with potent
antioxidant and anti-inflammatory effects.
Objectives: To evaluate the effects of chronic use of olanzapine on the anterior pituitary gland and the possible protective role
of hypericum perforatum
Material and method: Fifty six adult male albino rats were divided into 4 groups, received treatment orally for 8 weeks;
(I) control group, (II) HP supplemented group (80 mg/kg/day), (III) OLZ treated group (10 mg/kg/day), (IV) OLZ and HP
group (10 mg of OLZ and80 mg of HP/kg/day) . Finally, rats were weighted, anesthetized and sacrificed. Blood samples were
collected for biochemical study. Pituitary gland were dissected out and processed for histological study.
Results: Olanzapine treated rats exhibited a high significant increase in rat`s body weight. Plasma levels of luteinizing hormone
(LH) and follicle stimulating hormone (FSH) were significantly decreased but thyroid stimulating hormone (TSH) and prolactin
hormone were increased. OLZ induced degeneration of pars distalis cells. Where, cells had small dark nuclei and cytoplasmic
vacuolization. Eosinophilic material deposition and congestion of blood sinusoid were noticed. Most chromophiles contained
degenerated mitochondria and dilated rough endoplasmic reticulum. Furthermore, there was a high significant increase in the
number of positive caspase-3 immune-stained cells. Hypericum perforatum co-administration induced improvement of these
changes occurred by OLZ.
Conclusion: Olanzapine induced morphological and biochemical changes in the anterior pituitary gland. Hypericum
perforatum could ameliorate these changes.

Keywords

Caspase-3; EM; hypericum perforatum; olanzapine; pituitary gland.

Publication Link

https://doi.org/10.21608/ejh.2022.163482.1776

Block_researches_list_suggestions

Suggestions to read

HIDS-IoMT: A Deep Learning-Based Intelligent Intrusion Detection System for the Internet of Medical Things
Ahlem . Harchy Ep Berguiga
Generalized first approximation Matsumoto metric
AMR SOLIMAN MAHMOUD HASSAN
Structure–Performance Relationship of Novel Azo-Salicylaldehyde Disperse Dyes: Dyeing Optimization and Theoretical Insights
EBTSAM KHALEFAH H ALENEZY
“Synthesis and Characterization of SnO₂/α-Fe₂O₃, In₂O₃/α-Fe₂O₃, and ZnO/α-Fe₂O₃ Thin Films: Photocatalytic and Antibacterial Applications”
Asma Arfaoui
تواصل معنا