DETERMINATION OF HEMATOLOGICAL PARAMETERS AND D-DIMER AMONG SUDANESE CHILDREN INFECTED WITH PLASMODIUM FALCIPARUM IN KHARTOUM STATE – SUDAN.

Background: Falciparum malaria is one of the causes of morbidity and mortality in third world , the
pathogenesis of the infection results from the sequestration of infected hematological change in vital
organs.
Aim: this study aim to measuring hematological changes and D- dimer among children affected with P
falciparum.
Methods: The total study group100 children, 60 as case study infected with Plasmodium Falciparum
and 40 as control group healthy children. Hematological parameter measuring by hematological
analyzer and D dimer measured by fluorescence Immunoassay used I. Chroma instrument.
Results: Statistical analysis results of sixty children infected with malaria falciparum participated in the
study the mean±SD had a significantly lower Hb (8.14gm/dl ± 2.2) and haematocrit (24.4% ± 6.6) than
control children (p <0.001), Thrombocytopenia was found in 59.3% of enrolled patients. Platelet count
(98.53% ± 48.9), D. dimer (7397.58 ng/ml ± 5867.07) (p <0.001). D. dimer showed correlation with
parasite density, Platelet count and Haematocrit correlated (r = 0.4, p <0.0001); (p <0.001).
Conclusion: Malaria infection by plasmodium falciparum had major effects on hematological
parameters such as thrombocytopenia anemia and hyper coagulation have been significantly
associated with severity of malaria falciparum