Morphological Patterns of Elastic and Reticulum Fibers in Breast Lesions

Background: The difficulty with histopathology diagnosis is the presence of
numerous benign reactive breast lesions with morphological features mimic
malignant lesions. Thus, the objective of this study was to assess the merit of
morphological patterns of elastic and reticular fibers in differential diagnosis
of benign and malignant breast lesions. Methodology: Fifty biopsies were
obtained from females with breast Lesions (25 breast carcinoma and 25 benign lesions), their ages ranging from 17 to 85 years with mean age of 39
years old. Morphologic demonstrations of elastic and reticular fibers were
performed using conventional histochemical procedures. Results: Intense
grades of elastic fiber staining were achieved with carcinoma tissues. Dwindled grades of elastic fiber staining were detected with fibrocystic changes.
Elastic fibers in breast carcinoma are significantly increased compared to benign breast lesions P < 0.05. Reticular fibers have indicated relatively similar
presentation in benign and malignant breast lesions. Conclusion: Histochemical quantifications of elastic and reticular fibers can assist in routine
diagnosis of breast lesions. Elastic fibers significantly increase in breast carcinoma compared to benign breast lesions