تجاوز إلى المحتوى الرئيسي

Quality by design-based optimization of formulation parameters to develop quercetin nanosuspension for improving its biopharmaceutical properties

Author name : Ameeduzzafar Sarwar
Publication Date : 2022-03-27
Journal Name : South African Journal of Botany

Abstract

The present study describes the formulation, optimization and characterization of quercetin loaded nanosuspension. The formulation was prepared using liquid antisolvent precipitation technique. Optimization of formulation was done using Box-Behnken design by varying the concentration of sodium lauryl sulfate and polyvinyl pyrrolidone that were used as solubilizers. The processing parameters varied in this study were mixing speed and solvent to antisolvent ratio. The optimized formulation showed particle size of 202.15 ± 3.56 nm, zeta potential -20.26 ± 1.32 mV and drug loading 95.22 ± 2.45%. The results of dissolution and permeability studies showed about 26 folds enhancement in dissolution rate and 3.35 folds enhancement in permeability of quercetin through nanosuspension as compared to its raw form. The results of cell viability studies performed on Caco2 cells indicated more than 90% cell viability upon using nanosuspension, indicating safety of developed formulation. Furthermore, the formulation was found stable at accelerated stability conditions indicating the marketing potential of the developed formulation. Overall results showed the appropriateness of the developed formulation in enhancing the biopharmaceutical properties of quercetin.

Keywords

quercetin loaded nanosuspension

Publication Link

https://doi.org/10.1016/j.sajb.2022.04.030

Block_researches_list_suggestions

Suggestions to read

Generalized first approximation Matsumoto metric
AMR SOLIMAN MAHMOUD HASSAN
HIDS-IoMT: A Deep Learning-Based Intelligent Intrusion Detection System for the Internet of Medical Things
Ahlem . Harchy Ep Berguiga
Structure–Performance Relationship of Novel Azo-Salicylaldehyde Disperse Dyes: Dyeing Optimization and Theoretical Insights
EBTSAM KHALEFAH H ALENEZY
“Synthesis and Characterization of SnO₂/α-Fe₂O₃, In₂O₃/α-Fe₂O₃, and ZnO/α-Fe₂O₃ Thin Films: Photocatalytic and Antibacterial Applications”
Asma Arfaoui
تواصل معنا