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Three-component synthesis of arene-linked pyrazolo[1,5-a]pyrimidines

Author name : AHMED ABDELHAMID MOHAMED AHMED
Publication Date : 2023-05-29
Journal Name : Journal of Heterocyclic Chemistry

Abstract

n this study, we aimed to establish an efficient method for synthesizing two new series of arene-linked pyrazolo[1,5-a]pyrimidines. This was achieved by reacting 1H-pyrazole-3,5-diamines with the respective acetophenones and benzaldehydes in a 1:1:1 ratio. To optimize this three-component reaction, various bases, and solvents were investigated. Use of two equivalents of KOH in ethanol at reflux for 4–6 h resulted in 89%–96% yields of the desired products. Structure of new products was elucidated by considering their elemental and spectral data.

Keywords

Three-component synthesis- arene-linked pyrazolo[1,5-a]pyrimidines

Publication Link

https://doi.org/10.1002/jhet.4688

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