Analytical detection methods for diagnosis of COVID-19: developed methods and their performance

This mini review presents the standard methods for the analytical identification of virus species. These methods have been trusted and known as accredited methods. The development of new and improved analytical techniques is important to overcome the lack and the drawbacks of the well-known methods. Due to the uncertain and unprecedented time of pandemic, new approaches with high performance in the analysis are needed to retain the required and grow- ing diagnostic tools complementary to real-time polymerase chain reaction (RT-PCR) for COVID- 19 diagnosis. The researchers are still developing direct methods for the detection of SARS-CoV- 2 in a short turnaround time. The process of analytical validation is an important part of experi- mentation that is needed for the developed methods to be trusted. This review presents the major standard, commercial and designed methods for detecting SARS-CoV-2 and their analyt- ical performance. Also, chromatographic techniques have been introduced as a rapid examin- ation for SARS-CoV-2 identification, and the newly developed assays have been addressed.