Ruthenium Nanoparticles Uniformly-designed Chemically Treated Graphene Oxide Nanosheets for Simultaneous Voltammetric Determination of Dopamine and Acetaminophen

A new nanocomposite based on ruthenium
nanoparticles (RuNPs) uniformly designed at chemically
treated graphene oxide nanosheets (CTGONS) was
prepared as active electrode for simultaneously sensing of
dopamine (DA) and acetaminophen (AC) in the presence
of high concentration of ascorbic acid (AA). The RuNPs
actively decorates the CTGONS with uniform dispersion
like pump sputtering of paints. The CTGONS of hexagonal
nanosheets, 2D orientation, chemically treated to the
reduced forms and active decoration by RuNPs lead to
formation of high catalytic active sites and high loading of
targets at the electrode surface. The suitable accommodation
of RuNPs/CTGONS to fast response of targets
ascertains a high catalytic activity, and fast charge transport.
The RuNPs/CTGONS nanocomposite shows an
obvious catalytic oxidation signal for DA and AC. The
highly sensitive and selective electrode was designed
based on RuNPs/CTGONS due to the large peak
potentials separation of DA to AC of 0.22 V with
sufficient electron mediating behavior. Moreover, the
nanocomposite electrode shows individual and simultaneous
determination of DA and AC with linear calibration
plots from 5–120 μM and 10–120 μM, where their
detection limits were calculated to be 0.018�0.002 and
0.023�0.003 μM, respectively. Finally, the analytical application
of the RuNPs/CTGONS electrode was applied
for the determination of DA and AC in the serum of
human blood.