Association Between Serum Uric Acid Levels and Oxido-Inflammatory Biomarkers With Coronary Artery Disease in Type 2 Diabetic Patients

Background: Cardiovascular disease signifies a major cause of morbidity and mortality among patients with
type 2 diabetes mellitus (T2DM). Serum uric acid (SUA) levels are elevated during the initial phases of
impaired glucose metabolism. This work was designed to explore the association between SUA levels, serum
oxido-inflammatory biomarkers, and the risk of coronary artery disease (CAD) in T2DM patients as the
primary outcome. The secondary outcome was to assess the prognostic role of SUA in the prediction of the
risk of CAD in T2DM patients.
Methods: In this case-control study, we enrolled 110 patients with T2DM who were further divided into
patients with CAD and without CAD. In addition, 55 control participants were stringently matched to cases
by age.
Results: Diabetic patients with CAD had significantly higher serum levels of the inflammatory biomarkers
and the oxidative malondialdehyde but significantly lower levels of serum total antioxidant capacity (TAC)
compared with the controls and diabetic patients without CAD. Significant positive correlations existed
between SUA levels and serum levels of the inflammatory biomarkers and malondialdehyde, while a
significant negative correlation existed between SUA levels and serum TAC. SUA demonstrated an accepted
discrimination ability. SUA can differentiate between T2DM patients with CAD and patients without CAD,
an area under the curve of 0.759.
Conclusions: Elevated serum levels of SUA and oxido-inflammatory biomarkers are associated with an
increased risk of CAD in T2DM. SUA levels reflect the body's inflammatory status and oxidant injury in
T2DM. SUA could be utilized as a simple biomarker in the prediction of CAD risk in T2DM.