Histopathological Study on Mice Experimentally Infected With S. Mansoni and Treated By Neem and Mirazid

Generally, the parasitological markers showed that Neem (Azadirachta indica) and Mirazid
(Commiphora molmol, MZ) were effective in reducing worms and eggs of Schistosoma mansoni.
This study aimed to detect the histopathological improvement accompanied with using Neem and
Mirazid to treat schistosomiasis. A total of 120 Swiss Albino mice were categorized into 10
groups: 5 groups infected with S. mansoni and either treated with only Neem (400 mg/kg), only
MZ (500mg/kg), a combination of Neem and MZ, praziquantel (PZQ, 200 mg/kg) or not treated.
Other 5 control groups were not infected but acquired the same treated doses as the above groups.
The study was done in Department of Zoology, Faculty of Science, Al-Azhar University, Cairo,
Egypt. Hematoxylin eosin and Masson’s trichrome stain stained sections were used to examine
the histopathological changes in the intestine and liver of mice. The results showed marked
decrease of liver fibrosis in groups of mice treated with neem and/or MZ. This was ensured by a
significant diminution in number and diameters of granulomas, reduction in their fibrotic content
accompanied with a reduction in total area of infection as compared to infected mice.