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High performance liquid chromatographic(HPLC) method for the estimation of pitavastatin in pharmaceuticals.

Author name : Azhar Iqbal Mohammed Iqbal
Publication Date : 2022-05-01
Journal Name : Latin American Journal of Pharmacy

Abstract

An HPLC method was developed for the monitoring of pitavastatin in pharmaceuticals using C 18 column with detection wavelength at 278 nm. Phosphate buffer, acetonitrile and methanol with the ratio of 30:40:60 was selected as best mobile phase with pH 7.4 and pitavastatin was detected at 278 nm with flow rate of 1 mL/min. The retention time was 3.728 minute while the linearity was determined in the range of 300 to 800 ng/mL with 0.9997 coefficient of correlation. Percentage recoveries in terms of accuracy were in the range of 91.83 to 97.66%. Assay result of pitavastatin in self nanoemulsifying drug delivery system (SNEDDS) was 97.35 %. Method was successfully applied for determination of pitavastatin in developed SNEDDS due to its highest validity.

Keywords

Estimation, Nanoemulsifying

Publication Link

https://www.researchgate.net/publication/360670073_High_Performance_Liquid_Chromatographic_HPLC_Method_for_the_Estimation_of_Pitavastatin_in_Pharmaceuticals

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