Emerging targeted therapies in oral oncology: Focus on EGFR inhibition

This comprehensive study explored the role of epidermal growth factor receptor (EGFR)-targeted therapies in
oral cancer, focusing on emerging strategies, challenges, and future directions. The EGFR signalling pathway
plays a critical role in the development and progression of oral cancer, making it an attractive therapeutic target.
Small-molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) targeting EGFR have shown
promise in preclinical studies and clinical trials. However, challenges, such as the development of resistance

mechanisms and treatment-related toxicities, pose obstacles to their clinical utility. Future directions in EGFR-
targeted therapy include the exploration of combination therapies and the identification of predictive bio-
markers to optimize treatment strategies and improve patient outcomes in oral cancer.