Nano-Delivery Systems for Improving Therapeutic Efficiency of Dietary Polyphenols.

Dietary polyphenols – primarily categorized into flavonoids (flavanols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones) and nonflavonoids (stilbenes and phenolic acids) are reported to have health-promoting effects, such as antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral and cardioprotective properties. However, their applications in functional food and medications are limited due to their low bioavailability and insufficient systemic delivery, nano-delivery system conveyances frameworks astoundingly influence the take-up property of the stacked atoms because the molecule small shape, size, and surface properties of the nanoparticles apply a vital role in the improvement of polyphenols systemic delivery, such as Nano-emulsion, Nano-encapsulation, Polymers NPs, Nanoliposomes, Solid Liquid Nanoparticles, Cyclodextrins, and Polyphenols loaded Hydrogels.
Nano-technology is a rapidly developed area that guarantees the improvement of materials with novel measurements, new properties, and more extensive scope of utilizations. This review reported the different therapeutic applications of dietary polyphenols, their biological activities, and different Nano-delivery systems successfully developed for overcoming the delivery challenges, improve their bioavailability, reduced the toxicity, and enhance their uptake across the gastrointestinal tract.