Impact of Hydroxyurea Treatment on Thyroid Function Profile Among Chronic Myeloid Leukemia Patients in Khartoum Nuclear and Radiology Hospital.

Aim: To assess thyroid function hormones among chronic myeloid leukemia patientsunder hydroxyurea treatment Method:Thiscross-sectional study was conducted on CML patients using hydroxyl urea treatment protocolduring a period fromMarch to August 2019 at Khartoum nuclear and radiology hospitalTotal 100 participants, 53% females and 47 % males between 11 to 70 years of age were assessed for thyroid function parameters includingthyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine(FT4). Results: This studyrevealed that the thyroid hormones levels were increased among CML patients when compared with reference values. In addition,there was strong correlation between duration of drug usage andthyroid hormones levels. However, there was no statistical significant difference between hormones levels and gender. Conclusion: This study coluded that hydroxyurea treatment can increase thyroid hormones levels which maycause a serious metabolic disorders among CML patients