Development and Optimization of Setraconazole Invasomes, Gels, and Films for Enhanced Transdermal Delivery and Topical Fungal Treatment

This study was undertaken to improve the treatment of deep seated fungal skin infection by formulation of setraconazole loaded invasome gels and films. Setraconazole invasomes were prepared by thin-film hydration method and optimized by factorial design. The entrapment efficiency of the invasomes were determined. Invasomes with highest entrapment efficiency were further evaluated for size, zeta potential and converted to gels and films. Films and gels were evaluated for antifungal activity, skin irritation and in vitro skin permeation. Additionally gels were evaluated for pH, viscosity and spreadability. The invasomes showed high entrapment of setraconazole up to 83.4%. Further, invasomes were successfully converted into gels and films. The gels showed good consistency and excellent spreadability. Setraconazole gel (F4) and films containing tween 60 exhibited maximum permeation